Nintedanib for Improving Reproductive Outcomes in Adenomyosis

Inclusion Criteria: Aged 20-38, diagnosed with primary or secondary infertility; with at least one vitrified high-quality blastocyst (grading ≥4BB). Diagnosed with adenomyosis within the last 3 months by MRI or transvaginal ultrasound, meeting the criteria of the Chinese Expert Consensus on Diagnosis and Treatment of Adenomyosis. Body Mass Index (BMI) between 18-27 kg/m². Regular menstrual cycles, no amenorrhea or severe dysfunctional uterine bleeding. Normal ovarian reserve (AMH \> 1 ng/mL or AFC ≥ 5 per ovary), not currently receiving ovarian suppression therapy. Signed informed consent, able to understand and voluntarily participate, and willing not to participate in other clinical trials during the study period. Exclusion Criteria: Uterine or adnexal abnormalities (e.g., intrauterine adhesions, unicornuate/bicornuate/arcuate uterus, unremoved hydrosalpinx, endometrial polyp, submucosal myoma, or intramural myoma distorting the endometrial cavity). History of GnRH agonist injection within 3 months prior to embryo transfer. Unexplained abnormal vaginal bleeding. Known active pelvic inflammatory disease. Known genital malformation unsuitable for pregnancy. Abnormal cervical cytology (TCT) results within 1 year before screening. Severe impairment of liver or kidney function, heart disease, or hypertension. Known history of thrombophlebitis or thromboembolic disease. Any known clinically significant systemic disease (e.g., diabetes, tuberculosis). Known histor…