Background When babies are born too early (preterm), their lungs are often not fully developed. They may have trouble breathing because their airways and chest are not strong enough, and their lungs don't make enough surfactant (a natural substance that keeps the lungs open). This makes their tiny lungs collapse easily, causing breathing problems. Continuous Positive Airway Pressure (CPAP) is a safe and gentle way to help these babies breathe. CPAP works by sending a steady flow of air into the baby's nose, which keeps the lungs open and helps the baby breathe without needing a breathing machine (ventilator). The earlier CPAP is started after birth, the better it may help babies breathe more easily and reduce serious lung problems. Purpose of the Study This study will look at whether giving bubble CPAP to preterm babies immediately in the delivery room (within the first 10 minutes after birth) can lower the risk of breathing problems and death during their hospital stay. How the Study Will Be Done The research will take place at Bangabandhu Sheikh Mujib Medical University (BSMMU) in Dhaka. Babies born before 34 weeks of pregnancy who meet the study criteria will be included, with their parents' consent. Babies will be randomly divided into two groups: CPAP group - babies will be given bubble CPAP soon after birth in the delivery room. Control group - babies will receive only oxygen support in the delivery room. Both groups will then be moved to the Neonatal Intensive Care Unit (NICU) for further treatment as per hospital guidelines. The results will be compared to see which group had better outcomes. Expected Outcome We expect that starting bubble CPAP very early will help preterm babies breathe better, reduce the need for ventilators, and lower the risk of long-term breathing problems or death.
Age range
5 Minutes – 30 Minutes
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Need for mechanical ventilation
Timeframe: From birth until 7 completed days of life
Requirement for surfactant therapy
Timeframe: From birth until 7 completed days of life
Death within the early neonatal period
Timeframe: From birth until 7 completed days of life