Cocoa to Maximize Exercise Training in Older Adults - The COMET Trial (NCT07161726) | Clinical Trial Compass
RecruitingPhase 1/2
Cocoa to Maximize Exercise Training in Older Adults - The COMET Trial
United States36 participantsStarted 2026-04-21
Plain-language summary
The purpose of the study is to see if regular exercise when combined with a cocoa supplement will improve physical performance and muscle strength compared to regular exercise alone.
Who can participate
Age range55 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 55 years and older
* Slow walking speed of \< 1m/s
* Willingness to be randomized to either treatment group
* Willingness to participate in all study procedures (muscle biopsy will be optional)
Exclusion Criteria:
* Failure to provide informed consent;
* Regular consumption of flavanol and/or cocoa supplements
* Current involvement in supervised rehabilitation/exercise training program
* Absolute contraindication(s) to exercise training according to American College of Sports Medicine guidelines \[17\]
* Daytime average of systolic blood pressure ≥ 180/100mm Hg.
* Refusal to stop blood thinners such as baby aspirin dose.
* Peripheral vascular disease; peripheral neuropathy; retinopathy
* Severe cardiac disease, including NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina;
* Myocardial infarction or stroke within past year
* Significant cognitive impairment, including known dementia diagnosis or a Mini-Mental State Examination exam score \< 24
* Progressive, degenerative neurologic disease, e.g., Parkinson's Disease, multiple sclerosis;
* Severe rheumatologic or orthopedic diseases, e.g., awaiting joint replacement, active inflammatory disease;
* Severe pulmonary disease, requiring either steroid pills or injections or the use of supplemental oxygen;
* Hip fracture, hip or knee replacement, or spinal surgery within past 4 months;
* …
What they're measuring
1
6-min walk test
Timeframe: At the baseline, 6-week, and 12-week follow-up visits.