Investigating the Safety and Regenerative Potential of MSC-Derived Secretome Combined With PRGF in Knee Osteoarthritis

Inclusion Criteria: * Following is the inclusion criteria for the enrolment of patients affected with damaged cartilage in this study: * Diagnosed with primary OA in one or both knees based on American College of Rheumatology criteria * Grade I and II Arthritis * Joint pain ≥ 20mm measured by visual analogue scale * Age ranges from 30-55 years of age * BMI 27.12 ± 4.38 * Patients with no previous surgical interventions to lower limb * Willing to participate in the study Exclusion Criteria: * • Secondary OA due to trauma, infection, rheumatoid arthritis, congenital disease or other inflammatory disorders of the knee * Diagnosed with a systemic autoimmune disorder, immunodeficiency or coagulation disorder * Had history of malignancy * History of allergy or allergic constitution * Pregnant or breastfeeding women.