Biotin-Acridine Red Cell Exchange Kinetics

Inclusion Criteria: * Age ≥18 years * homozygous sickle cell disease (HbSS) or Hemoglobin S-β-thalassemia (HbSβ0) SCD * Receiving RCE for ≥3 months prior to enrollment and scheduled to undergo at least 4 sequential RCE episodes during the period of enrollment in the study Exclusion Criteria: * Anticipated cessation of RBC transfusion therapy in the next ≤2 months * Planned stem cell transplant or gene therapy in the next 6 months * Delayed hemolytic transfusion reaction in the past 3 months * History of hyperhemolysis syndrome at any time * Consuming high-dose biotin or raw egg supplements * Current pregnancy * Antibody specific to INTERCEPT RBCs or biotinylated red blood cells (BioRBCs) at baseline * Patients with RBC alloantibodies that make it difficult to provide antigen matched blood.