This study aims to verify transcranial direct current stimulation(tDCS) efficacy for Parkinson's disease (PD)-related dysphagia and its mechanism. Subjects are randomly split into two groups: control (sham tDCS + conventional dysphagia treatment) and experimental (real tDCS + conventional treatment). Assessments will be conducted at baseline, after the completion of intervention, and at the 3-month follow-up. Swallowing function will be evaluated via gold-standard videofluoroscopic swallowing study (VFSS) and scales. Resting-state functional magnetic resonance imaging (rs-fMRI) or functional near-infrared spectroscopy (fNIRS) will be measures for tracking changes in abnormal brain regions/networks. Correlations between swallowing recovery and brain function changes, plus group imaging differences, will reveal tDCS's neurophysiological mechanism.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Rosenbek Penetration-Aspiration Scale (PAS):
Timeframe: at baseline, after the completion of 10 days of intervention, at the 3-month follow-up
Videofluoroscopic Dysphagia Scale (VDS)
Timeframe: at baseline, after the completion of 10 days of intervention, at the 3-month follow-up
oral residue
Timeframe: at baseline, after the completion of 10 days of intervention, at the 3-month follow-up
Amplitude of Low Frequency Fluctuation (ALFF)
Timeframe: at baseline, after the completion of 10 days of intervention, at the 3-month follow-up
Functional Connectivity (FC)
Timeframe: at baseline, after the completion of 10 days of intervention, at the 3-month follow-up
vellaculae residue
Timeframe: at baseline, after the completion of 10 days of intervention, at the 3-month follow-up
pyriform sinuses residue
Timeframe: at baseline, after the completion of 10 days of intervention, at the 3-month follow-up