Brain Stimulation Effects on Post-Stroke Fatigue and Aphasia (NCT07151677) | Clinical Trial Compass
RecruitingNot Applicable
Brain Stimulation Effects on Post-Stroke Fatigue and Aphasia
United States60 participantsStarted 2025-08-04
Plain-language summary
The goal of this clinical trial is to determine if electrical brain stimulation applied to the front parts of the brain can help people who have had a stroke improve their fatigue, language, and attention. The main question it aims to answer is:
* Does transcranial direct current stimulation (tDCS) administered to the pre-frontal areas of the brain improve post-stroke fatigue and aphasia?
* What kinds of participant characteristics are associated with better improvement of post-stroke fatigue and aphasia?
Researchers will compare active electrical stimulation to sham stimulation to see if the active stimulation does a better job at reducing fatigue and language deficits after stroke. Participants will be asked to complete fatigue, language, and cognitive testing before and after receiving 10 sessions of tDCS plus speech and language therapy.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. 18 years or older.
✓. No diagnosis of neurological disorder (other than stroke).
✓. No diagnosis of psychiatric disorder, with the exception of anxiety and/or depression if it is managed through medication and/or behavioral intervention.
✓. No seizure within the past 6 months.
✓. Not pregnant.
✓. Does not currently have cardiac pacemaker
✓. In chronic phase of recovery, defined as at least 6 months post-stroke.
✓. Not undergoing speech and language therapy targeting auditory comprehension or attention for the duration of the study.
Exclusion criteria
✕. Younger than 18 years old.
✕. Diagnosis or history of neurological disorder other than stroke.
What they're measuring
1
Fatigue Interference and Severity Scale for Aphasia (FISS-A)
Timeframe: baseline; within 1 week following the final treatment session; 3- month follow-up
. Diagnosis or history of psychiatric disorder with the exception of anxiety and/or depression if it is managed through medication and/or behavioral intervention.
✕. History of seizures within the past 6 months.
✕. Pregnant.
✕. Currently has cardiac pacemaker
✕. \<6 months post-stroke (however, if this is only exclusionary criterion met, participant can be re-evaluated at the 6-month mark if still interested in the study)
✕. Currently undergoing speech and language therapy targeting auditory comprehension or attention.