Phonophoresis With Bee Venom: Evaluating Its Efficacy in Managing Pain and Enhancing Mobility in … (NCT07151300) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Phonophoresis With Bee Venom: Evaluating Its Efficacy in Managing Pain and Enhancing Mobility in Knee Osteoarthritis Patients
Egypt30 participantsStarted 2026-08-15
Plain-language summary
Brief Summary:
This single-blind, randomized controlled trial will investigate the efficacy of bee venom phonophoresis in managing pain and improving mobility in patients with knee osteoarthritis. Thirty adults aged 40-75 years with clinically and radiographically confirmed knee osteoarthritis will be randomly assigned to receive either bee venom phonophoresis or placebo phonophoresis with a neutral gel. Ultrasound parameters will be standardized for all participants.
Primary outcomes are pain reduction, measured by the Visual Analog Scale (VAS), and functional mobility, assessed by the Timed Up and Go (TUG) test. The secondary outcome is walking endurance, measured by the Six-Minute Walk Test (6MWT). Assessments will be conducted at baseline and post-intervention.
The study is designed to determine whether bee venom phonophoresis offers greater clinical benefit compared to placebo phonophoresis, potentially providing a non-invasive, adjunctive treatment option for knee osteoarthritis. Ethical approval has been obtained from the Faculty of Physical Therapy, Sinai University, and all participants will provide written informed consent.
Who can participate
Age range
40 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 40-75 years
* Clinically and radiographically confirmed knee osteoarthritis
* Moderate to severe pain (VAS ≥ 4)
* Willingness to provide informed consent
Exclusion Criteria:
* Allergy to bee products or topical agents used in the study
* Knee surgery or trauma in the past year
* Intra-articular injection in the past 6 months
* Other musculoskeletal or systemic conditions affecting the knees (e.g., rheumatoid arthritis)
* Pregnancy or contraindication to ultrasound therapy
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial uses bee venom applied through ultrasound waves — called phonophoresis — which is different from a standard injection or cream. Can you explain how this delivery method works and whether there's any known risk of allergic reaction I should be aware of before even considering it?
2The trial is listed as 'not yet recruiting,' which means it hasn't started enrolling patients. How long do you think it might be before it opens, and would it make sense for me to start a more established treatment for my knee osteoarthritis in the meantime?
3This study is measuring changes in pain intensity and functional mobility as its main outcomes, but it's listed as Phase NA, meaning it may be more exploratory. Does that affect how confident we can be about whether the bee venom phonophoresis is safe and effective compared to treatments we already know work?
4Since bee venom is the active ingredient here, is there any allergy testing or screening I should discuss with you before I could even be considered for something like this, given that some people have serious reactions to bee stings?
5Are there existing standard treatments for knee osteoarthritis — like physical therapy, corticosteroid injections, or hyaluronic acid — that you think I should try first, or does my specific situation make a trial like this worth exploring sooner?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Pain Intensity
Timeframe: Baseline (day 0), mid-intervention (week 2), and end of intervention (week 4).
2
Change in Functional Mobility
Timeframe: Baseline (day 0), mid-intervention (week 2), and end of intervention (week 4).