To Assess the Efficacy of a Toothpaste Containing 8% Arginine as Compared to Colgate Cavity Prote… (NCT07149376) | Clinical Trial Compass
CompletedPhase 3
To Assess the Efficacy of a Toothpaste Containing 8% Arginine as Compared to Colgate Cavity Protection Toothpaste in the Reduction of Dentinal Hypersensitivity.
United States84 participantsStarted 2025-08-18
Plain-language summary
The objective of this clinical investigation is to assess the efficacy of a toothpaste containing 8% arginine (Colgate-Palmolive Company, New York, NY, USA) as compared to a commercially available non-desensitizing toothpaste (Colgate Cavity Protection Toothpaste, Colgate-Palmolive Company, New York, NY, USA) in the reduction of dentinal hypersensitivity over an eight (8) week period.
Who can participate
Age range18 Years – 70 Years
SexALL
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Inclusion Criteria:
* Sign an Informed Consent Form;
* Male or female 18 to 70 years of age, inclusive;
* Be in good general health as determined by the study investigators;
* Available for the eight (8) weeks duration of the study;
* Must present two (2) sensitive teeth which must meet ALL of the following criteria:
* Be anterior to the molars and demonstrating dentin exposure due to cervical erosion/abrasion and/or gingival recession;
* Have a qualifying dentin hypersensitivity response to tactile stimuli applied to the cervical surface (gingivo-facial 1/3) as defined by a response score between 10-50grams of force (Yeaple Probe, XiniX Research Inc. Portsmouth, NH, USA);
* Have a qualifying dentin hypersensitivity response to air blast stimuli applied for one second to the cervical surface (gingivo-facial 1/3) as defined by a score of 2 or 3 on the Schiff Cold Air Sensitivity Scale.
Exclusion Criteria:
* Gross oral pathology, chronic disease, and/or history of allergies to any of the test products
* Use of a desensitizing oral care product and/or recipient of any dental desensitizing treatment within the past three months prior to start of the study;
* Advanced periodontal disease and/or treatment for periodontal disease (including surgery) within the past twelve months
* Sensitive teeth with a mobility greater than one Teeth with extensive/defective restorations (including prosthetic crowns), suspected pulpitis, caries, cracked enamel, or used as abutments for removable…