Comparison of Upper and Lower Limb Maximal Exercise Capacities and Arterial Stiffness in Patients… (NCT07148518) | Clinical Trial Compass
CompletedNot Applicable
Comparison of Upper and Lower Limb Maximal Exercise Capacities and Arterial Stiffness in Patients With CAD
Turkey (Türkiye)30 participantsStarted 2025-09-01
Plain-language summary
Coronary artery disease (CAD) significantly increases mortality rates in both developed and developing countries. In this condition, the impairment of arterial blood circulation leads to insufficient blood supply to the myocardium during both rest and exercise, resulting in symptoms such as angina pectoris, dyspnea, and fatigue. Patients, particularly due to their fear of experiencing angina pectoris, tend to adopt a sedentary lifestyle. This situation contributes to exercise intolerance and a reduction in exercise capacity among individuals with CAD. A review of the literature reveals a lack of studies investigating upper and lower extremity exercise capacity and the physiological responses during exercise testing in patients with CAD. Therefore, the aim of this study is to compare arterial stiffness, muscle oxygenation, respiratory muscle fatigue, energy expenditure, perceived dyspnea, and fatigue during upper and lower extremity exercise testing in patients with coronary artery disease.
Who can participate
Age range
18 Years – 85 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 18-85 with coronary artery disease diagnosed by conventional or CT angiography
* Clinically stable
* Willing to participate
Exclusion Criteria:
* Heart failure diagnosis
* Moderate/severe valvular heart disease
* Orthopedic, neurological, or pulmonary conditions limiting exercise testing/capacity
* Contraindications per ACSM guidelines
* Prior coronary artery bypass graft surgery
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study compared upper versus lower limb exercise capacity in people with coronary artery disease — based on what those results showed, should I be doing arm-based exercise, leg-based exercise, or both as part of my cardiac rehab or management plan?
2The trial measured arterial stiffness using pulse wave velocity and augmentation index — do you think testing my arterial stiffness in these ways would give us useful information about my cardiovascular risk or how well my current treatment is working?
3Since this study is already completed, are the findings available, and can you walk me through what they might mean for someone with my specific type of coronary artery disease?
4This trial focused on measuring and comparing capacities rather than testing a new treatment — does that mean its findings are more about understanding my condition than changing my therapy, and how does that affect how relevant it is to my care?
5Given what this study looked at around exercise capacity and artery stiffness, are there any changes to my current exercise routine or monitoring approach that you think would be worth discussing now?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Maximal Exercise Capacity
Timeframe: Through study completion, an average of 1 year