Dronabinol and Epidiolex to Manage Uncontrolled Residual Symptoms of Buprenorphine Initiation Trial

Inclusion Criteria: * Fluency in English and Spanish * The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnosis of OUD * Newly initiated on buprenorphine within 21 days * Positive urine toxicology for opioids other than buprenorphine in the past week OR opioid withdrawal symptoms in the past week based on the Clinical Opioid Withdrawal Scale (COWS) \>=5 * Any cannabis use in the past at or after the age of 18 years based on self-report Exclusion Criteria: * Urine toxicology positive for cannabinoids * Inability to provide informed consent * Liver tests (AST or ALT) \>3 times the upper limit of normal, or a history of liver disease * Pregnancy or breast/chest feeding * Unstable cardiac disease, history of hypotension or syncope * Psychotic disorder, or history of suicidal behavior and/or ideation * Progressive neurological conditions, frequent falls, or history of epileptic seizures * Severe alcohol use disorder, benzodiazepine use disorder or stimulant use disorder * Other serious medical conditions that would be a contraindication to THC or CBD use