Not Yet RecruitingNot Applicable

Virtual Reality Intervention for Symptom Management in Stem Cell Transplantation

30 participantsStarted 2025-09-10

Plain-language summary

The goal of this clinical trial is to evaluate whether a virtual reality (VR) intervention based on the Symptom Management Model can reduce physical and psychosocial symptoms during hematopoietic stem cell transplantation (HSCT) in adult patients undergoing allogeneic transplantation. The main questions it aims to answer are: Does the VR intervention reduce distress levels during HSCT? Does the VR intervention decrease state anxiety and symptom severity compared to standard care? Does the VR intervention positively affect physiological outcomes and engraftment times? Researchers will compare a group receiving standard clinical care plus a VR nature-themed video during HSCT to a group receiving standard care only to see if the VR intervention improves symptom management outcomes. Participants will: Be randomly assigned to either the intervention or control group. In the intervention group: Watch a 15-minute nature-themed VR video during stem cell infusion using Meta Quest 3. The video content will be specifically created by the research team based on the principles of Attention Restoration Theory (ART). In both groups: Complete pre- and post-intervention assessments including: Distress Thermometer State-Trait Anxiety Inventory Edmonton Symptom Assessment Scale Physiological measures (vital signs) Engraftment tracking Satisfaction and open-ended feedback forms

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients aged 18 years or older * Able to speak and understand Turkish * Scheduled to undergo allogeneic hematopoietic stem cell transplantation (HSCT) * Receiving stem cell products collected from peripheral blood * Voluntarily agree to participate in the study and provide informed consent Exclusion Criteria: * Undergoing autologous hematopoietic stem cell transplantation * Receiving stem cell products collected from bone marrow * Diagnosed with medical or psychiatric comorbidities that could interfere with participation, as reported by the healthcare team * Presenting infection symptoms (e.g., respiratory, gastrointestinal) that may contaminate study equipment, as identified by the healthcare team * Having visual, auditory, verbal, or cognitive impairments that may prevent interaction with the VR equipment * Previously received any form of hematopoietic stem cell transplantation

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in Distress Level

Timeframe: From 15 minutes before HSCT infusion to 15 minutes after the start of infusion

Change in State Anxiety

Timeframe: From 15 minutes before HSCT infusion to 15 minutes after the start of infusion

Change in Symptom Severity

Timeframe: 15 minutes before HSCT infusion to 15 minutes after the start of infusion

Trial details

NCT IDNCT07145359

SponsorHalic University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-06-10

View on ClinicalTrials.gov More Cancer and / or Hematological Malignancy trials

Plain-language summary

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in Distress Level

Timeframe: From 15 minutes before HSCT infusion to 15 minutes after the start of infusion

Change in State Anxiety

Timeframe: From 15 minutes before HSCT infusion to 15 minutes after the start of infusion

Change in Symptom Severity

Timeframe: 15 minutes before HSCT infusion to 15 minutes after the start of infusion