DK222 Study at Hopkins

Inclusion Criteria: * Subjects must sign informed consent prior to inclusion in this trial. * Subjects must be ≥18 years of age and competent to give informed consent. * Subjects must be diagnosed with histologically confirmed NSCLC or UC and eligible for anti-PD(L)-1 therapy. * PD-L1 immunohistochemistry result using a Clinical Laboratory Improvement Amendments (CLIA) assay must be available or if not available then sufficient tissue must be available to perform PD-L1 testing. * Subjects must score at least 0 to 2 on the Eastern Cooperative Oncology Group (ECOG) Performance Status. * Subjects must have adequate organ function as defined by the following laboratory values (determined within 28 days prior to randomization/registration) or as deemed not clinically significant by physician on record: * White blood cells (WBC) ≥ 2000 /μL * Absolute neutrophil count (ANC) ≥ 1500 /μL * Platelets ≥ 100 x103 /μL * Hemoglobin ≥ 9 g/dL or ≥ 5.6 mmol/L * Serum creatinine ≤ 1.5 times upper limit of normal (ULN) or creatinine clearance greater than or equal to 60 ml/min (using the Cockcroft-Gault formula) * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3 times ULN * Bilirubin ≤ 1.5 times ULN (Except patients with the Gilbert Syndrome, for whom a maximum of ≤ 3.0 mg/dL is acceptable) * Women of childbearing potential (WOCBP) should have a negative serum pregnancy test within 24 hours prior to receiving the first administration \[18F\]DK222. Women wit…