RecruitingNot Applicable

Hemodynamic Effects of Surgical Position in Prone vs. Supine Percutaneous Nephrolithotomy

Turkey (Türkiye)84 participantsStarted 2025-06-01

Plain-language summary

This prospective, randomized controlled study evaluates the hemodynamic effects of prone and supine positions during percutaneous nephrolithotomy (PNL) for large kidney stones. Surgical position may influence intraoperative and postoperative hemodynamic stability. Prone positioning can increase intrathoracic pressure and reduce venous return, whereas supine positioning may provide greater hemodynamic stability. A total of 84 patients will be randomized to undergo PNL in prone or supine positions. Primary outcomes include changes in hemodynamic parameters during surgery. Results may guide surgical position selection, especially in patients with potential hemodynamic risk.

Who can participate

Age range

18 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * ASA physical status I-III * Presence of renal calculi indicated for PNL Exclusion Criteria: * Pregnancy * Uncontrolled coagulopathy * Previous renal surgery * Severe cardiac, pulmonary, or neurological disease * Preoperative urinary tract infection (non-sterile urine culture) * Surgery duration \<60 minutes or \>120 minutes * Preoperative blood transfusion * Multiple access tracts

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in Hemodynamic Parameters (Intraoperative)

Timeframe: From induction of anesthesia to the end of surgery (approximately 60-120 minutes)

Change in Arterial Blood pH

Timeframe: Preoperative, intraoperative, postoperative day 1

Change in Diastolic Blood Pressure (Intraoperative)

Timeframe: From induction of anesthesia to the end of surgery (approximately 60-120 minutes

Change in Mean Arterial Pressure (Intraoperative)

Timeframe: From induction of anesthesia to the end of surgery (approximately 60-120 minutes)

Change in Heart Rate (Intraoperative)

Timeframe: From induction of anesthesia to the end of surgery (approximately 60-120 minutes)

Change in Arterial pO₂

Timeframe: Preoperative, intraoperative, postoperative day 1

Change in Arterial HCO₃-

Timeframe: Preoperative, intraoperative, postoperative day 1

Trial details

NCT IDNCT07138872

SponsorGaziosmanpasa Research and Education Hospital

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2025-12-30

Contact for this trial

ARİF BURAK KEÇEBAŞ, UROLOGY CLINIC DOCTOR

+90 5412659978 arifkecebas@gmail.com

View on ClinicalTrials.gov More Percutaneous Nephrolithotomy (PCNL) trials

Plain-language summary

Who can participate

Age range

18 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in Hemodynamic Parameters (Intraoperative)

Timeframe: From induction of anesthesia to the end of surgery (approximately 60-120 minutes)

Change in Arterial Blood pH

Timeframe: Preoperative, intraoperative, postoperative day 1

Change in Diastolic Blood Pressure (Intraoperative)

Timeframe: From induction of anesthesia to the end of surgery (approximately 60-120 minutes

Change in Mean Arterial Pressure (Intraoperative)

Timeframe: From induction of anesthesia to the end of surgery (approximately 60-120 minutes)

Change in Heart Rate (Intraoperative)

Timeframe: From induction of anesthesia to the end of surgery (approximately 60-120 minutes)

Change in Arterial pO₂

Timeframe: Preoperative, intraoperative, postoperative day 1

Change in Arterial HCO₃-

Timeframe: Preoperative, intraoperative, postoperative day 1