A Phase 3 Study of VVN461 Ophthalmic Solution for Noninfectious Anterior Uveitis (NCT07136805) | Clinical Trial Compass
Not Yet RecruitingPhase 3
A Phase 3 Study of VVN461 Ophthalmic Solution for Noninfectious Anterior Uveitis
152 participantsStarted 2025-10-01
Plain-language summary
This is a multicenter, randomized, single-masked, active-controlled, parallel, Phase III pivotal study in China
Who can participate
Age range
18 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* At the time of signing the informed consent form (ICF), the subject must be aged 18 to 70 years (inclusive);
* At screening, the affected eye is diagnosed with non-infectious anterior uveitis (acute or recurrent acute, only unilateral eye affected patients are included);
* At screening, the ACC grade of the affected eye is 2+ or 3+ \[SUN criteria\];
* At screening, the ACF grade of the affected eye is ≥1 \[SUN criteria\];
Exclusion Criteria:
* At screening, the affected eye has an ACC grade of 4+ or hypopyon
* Diagnosis of intermediate uveitis, posterior uveitis, or panuveitis in either eye at the time of screening
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change from baseline in anterior chamber cell (ACC) grade in the study eye at Day 14