Phase I Study of Safety and Feasibility of Transarterial Embolization of Incurable Hypervascular Pediatric Soft Tissue Sarcomas

Inclusion Criteria: * Pediatric patient aged 2-18 years, weighing at least 20 kg * Diagnosed with biopsy proven primary or metastatic soft tissue sarcoma designated as a non-curative surgical candidate and/or failure of standard of care chemotherapy/immunotherapy with local progression on 3-month post induction imaging * Staging CT or MRI demonstrating at least 50% arterial vascularity by volume within at least one tumor measuring at least 3 cm in longest dimension with an identifiable arterial feeder within one month of screening visit Exclusion Criteria: * Negative pregnancy test within 48 hours of angiography or lactation for females of childbearing age * Known anaphylactic allergic reactions to iodinated contrast * Planned surgery or radiation to the target site within the study period at time of enrollment