Identifying Fundamental Mechanisms of Skeletal Muscle Ageing in Older Men Undergoing Androgen Deprivation Therapy: a Feasibility Study

Inclusion Criteria: * Age ≥65 years old at time of recruitment * Able to provide informed consent to participate * Known prostate cancer due to be initiated on ADT for the first time (with or without Androgen Receptor Targeted Agents (ARTA) or radiotherapy), or initiated within two weeks prior to recruitment. * Individuals involved in other research will be eligible to participate so long as the other research does not involve potential changes to the standard ADT care the participant will be receiving and does not involve an intervention aimed at reducing the muscle atrophy associated with ADT. Exclusion Criteria: * Systemic anti-cancer therapy within one year of recruitment (for prostate cancer or any other concomitant cancer) * Planned surgery (not including eye surgery or other minor surgery) within six months of ADT * Any other condition previous or current which, in the judgement of the responsible clinician, is likely to interfere with the trial / assessments. * Lacks capacity to consent Exclusion criteria for those consenting to optional muscle biopsy: * On treatment with clopidogrel, high-dose aspirin, dipyridamole or anticoagulants * Known bleeding disorder or platelets \<75x103/mL