This pilot open-label study will assess the feasibility, acceptability, and preliminary efficacy of targeted (as-needed) oral naltrexone in individuals participating in "Dry January," a month-long voluntary abstinence or reduction in alcohol use. Participants who do not meet criteria for alcohol use disorder (AUD) but are interested in reducing or abstaining from alcohol will receive a 31-day supply of 50mg oral naltrexone to take either prior to anticipated drinking or daily as a precaution. The study will evaluate recruitment, retention, adherence, and safety, as well as changes in alcohol use patterns, craving, mood, liver function, and quality of life. A qualitative interview at follow-up will explore participants' experiences using naltrexone during Dry January. Results will inform future randomized trials testing low-intensity, scalable interventions for non-treatment-seeking individuals seeking to reduce alcohol consumption.
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Recruitment feasibility
Timeframe: Up to 3 business days following baseline visit
Retention feasibility
Timeframe: Up to 3 business days following baseline visit
Intervention acceptability
Timeframe: Up to 3 business days following baseline visit
Naltrexone adherence
Timeframe: 1 month during the month of Januaray 2026
Safety Measure
Timeframe: Up to 3 business days following baseline visit