The purpose of this study is to learn how the body processes the study medicine PF-07104091. The study is seeking participants who are: \- Healthy male aged 18 to 65 years of age Participants in the study will receive 14C-labeled PF-07104091 by mouth after a meal. After 14 days, the participants will receive PF-07104091 by mouth (after a meal) followed by IV fusion (given directly into a vein) of microdose \[14C\]PF-07104091. The study will help understand how the body processes study medicine PF-07104091 and how the medicine is changed and removed from the body after you take it. This study will also help to understand how much PF-07104901 is taken up into the blood. Participants will remain in the study clinic for a maximum of 23 days and will have one follow-up contact.
Age range
18 Years – 65 Years
Sex
MALE
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Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Percentage of Total Radiocarbon (14c) excreted in urine
Timeframe: From Predose up to 14 days post dose of period 1 and 2
Percentage of Total Radiocarbon (14c) excreted in feces
Timeframe: From Predose up to 14 days post dose of period 1 (and if applicable for Period 2)
Percentage of Total Radiocarbon (14c) excreted in vomitus (if applicable)
Timeframe: From Predose up to 14 days post dose of period 1 only
Cumulative Percent Recovery of Total Radiocarbon (14C)
Timeframe: From Predose up to 14 days post dose of period 1 only
Percentage of Metabolite Detected in Plasma After Oral Administration of PF-07104091
Timeframe: From Predose to 14 days post dose of period 1
Percentage of Metabolite Detected in Urine After Oral Administration of PF-07104091
Timeframe: From Predose to 14 days post dose of period 1
Percentage of Metabolite Detected in Feces After Oral Administration of PF-07104091
Timeframe: From Predose to 14 days post dose of period 1