RecruitingNot Applicable

Immersive Virtual Reality in Cognitive Rehabilitation of Patients With Post-Stroke Cognitive Impairment

Chile20 participantsStarted 2025-08-06

Plain-language summary

This pilot study aims to evaluate the feasibility of implementing immersive virtual reality (VR) in cognitive rehabilitation for adults with post-stroke cognitive impairment receiving outpatient therapy. Participants will use a head-mounted display and interactive software to engage in gamified cognitive exercises that simulate memory, attention, and executive function tasks. The intervention consists of 10 sessions, delivered two to three times per week over a period of approximately four weeks. The study will assess multiple feasibility indicators, including the recruitment rate based on eligibility criteria, the safety and tolerability of VR sessions for participants, and the usability and satisfaction reported by occupational therapists administering the intervention. Additionally, exploratory outcomes include changes in global cognition and specific cognitive domains, as well as self-reported quality of life. Adverse effects related to VR use will be tracked. This pilot study will help inform the design and implementation of future, larger-scale clinical trials.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients over 18 years of age * Patients with a cerebrovascular accident of any etiology with less than 3 months of progression * Patients with mild to moderate cognitive impairment post-stroke (impairment in at least one cognitive domain) * MoCA score of less than 24 points * Referred for cognitive rehabilitation at the Occupational Therapy Unit of HCUCH Exclusion Criteria: * Patients with refractive errors that prevent the use of the headset * Patients with any type of aphasia that prevents the administration of the MoCA test * Patients with severe psychiatric disorders (presence of psychotic symptoms or derealization) * Patients with severe motor impairments (lack of trunk control or global strength of both upper limbs \< M3)

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Proportion of participants who complete ≥80% of planned sessions.

Timeframe: From first session to week 5 (after completion of the 10-session VR program)

Incidence of VR-related adverse events requiring session interruption

Timeframe: From first session to week 5 (after completion of the 10-session VR program)

Therapist-reported usability and satisfaction with immersive virtual reality in cognitive rehabilitation

Timeframe: At week 5 (after completion of the 10-session VR program)

Trial details

NCT IDNCT07125170

SponsorUniversity of Chile

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-05-01

Contact for this trial

Natalia Gattini, MD

+56989019110 ngattini@hcuch.cl

View on ClinicalTrials.gov More Stroke trials

Plain-language summary

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Proportion of participants who complete ≥80% of planned sessions.

Timeframe: From first session to week 5 (after completion of the 10-session VR program)

Incidence of VR-related adverse events requiring session interruption

Timeframe: From first session to week 5 (after completion of the 10-session VR program)

Therapist-reported usability and satisfaction with immersive virtual reality in cognitive rehabilitation

Timeframe: At week 5 (after completion of the 10-session VR program)