Dose Escalation Trial of CD40.Pan.CoV Vaccine, Adjuvanted or Not, as a Booster in Adult Healthy Volunteers

Inclusion criteria

• ✓. Age ≥18 and \<65 years at the day of screening.
• ✓. Able to understand and comply with planned trial procedures and willing to be available for all trial-required procedures, visits and calls for the duration of the trial.
• ✓. Voluntarily signed written informed consent before performance of any trial-related screening procedures.
• ✓. Being covered by the Health Insurance.
• ✓. Agree to be registered in the French Health Ministry computerized file.
• ✓. In healthy condition or with stable health status which is defined as an existing disease that has not required a significant change in treatment or hospitalization for worsening before enrolment, and for which neither a significant change in treatment or hospitalization for worsening is expected in the near future.
• ✓. Subject who has received : 2 doses of COVID-19 vaccine with a history of COVID-19 infection or at least 3 doses of COVID-19 vaccine (including at least 1 booster of mRNA vaccination). The last dose should be at least 6 months prior to the inclusion.
• ✓. Subject who has normal biological values:

Exclusion criteria