Seroprevalence of Brucella Antibodies in High-Risk Patients With Low Back Pain: A Case-Control Study (NCT07112677) | Clinical Trial Compass
CompletedNot Applicable
Seroprevalence of Brucella Antibodies in High-Risk Patients With Low Back Pain: A Case-Control Study
Egypt100 participantsStarted 2024-02-01
Plain-language summary
The goal of this observational case-control study is to assess the presence of Brucella antibodies in patients with low back pain who are at high risk for brucellosis exposure, such as those with animal contact or consumption of unpasteurized dairy products. The main question it aims to answer is:
Is there a significant association between Brucella seropositivity and low back pain in high-risk individuals?
Researchers will compare patients with low back pain to age- and sex-matched healthy controls without back pain but with similar exposure risks, to see if Brucella antibodies are more frequent in the patient group.
Participants will:
Undergo a detailed clinical history and physical examination
Provide blood samples for serological testing using ELISA for Brucella IgG/IgM/IgA
Be evaluated for other symptoms such as fever, fatigue, and joint pain
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults of any sex at high risk of Brucella exposure (e.g., contact with livestock or consumption of unpasteurized dairy products)
* Patients presenting with non-specific low back pain
* Willing and able to provide informed consen
Exclusion Criteria:
* Evidence of tuberculosis (Pott's disease)
* Evidence of septic spondylitis
* Known metastatic bone lesions
* Known degenerative or autoimmune rheumatologic spinal diseases
* History of prior spinal surgery or trauma
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Prevalence of Brucella Antibodies in High-Risk Patients with Low Back Pain
Timeframe: February 2024 to February 2025
2
Prevalence of Brucella Antibodies in High-Risk Patients with Low Back Pain