WithdrawnNot Applicable

Cost-effectiveness Analyses for the Prevention of Acute Kidney Injury in Patients Undergoing Cardiac Surgery in the UK

Stopped: Funded by company allocated elsewhere.

United Kingdom0Started 2026-03

Plain-language summary

Multi-centre retrospective analysis of prospectively collected data with propensity matched scoring groups (AKI v/s non-AKI). Data collection from databases (or their equivalent): PATS Dendrite, Electronic Medical Records, TD-web (results Portal), MedTrack (ICU database), iSite (Radiology), SPY (Long-term status)

Who can participate

SexALL

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Inclusion criteria

✓. Patients undergoing cardiac surgery (elective or in-house urgent) from Jan 1st, 2013, to December 31st, 2023 (excluding patients during 2020 \& 2021 - due to confounding Covid-19 impact on AKI)
✓. Cardiopulmonary bypass machine was used during cardiac surgery
✓. Patient's data available in the databases (Minimum dataset required for propensity matching: age, gender, diabetes history, LVEF, priority of surgery, pre-op haemoglobin \& SCr levels, cardiac surgery performed, CPB duration, Euroscore or LogEuroscore, RRT use, post-op D1\&/or D2 \&/or D3 SCr)

Exclusion criteria

✕. Emergency surgery
✕. Patient with incomplete dataset\*
✕. Surgery performed without CPB
✕. Patients already dialysis dependent
✕. Patient with eGFR \<20 mL/min/1.73 m²
✕. Cardiac surgery requiring deep hypothermic circulatory arrest (DHCA)
✕. Patients previously treated with RenalGuard® Therapy
✕. Patient has opted-out of research (data opt-out) \* Data completeness - These variables need to be complete for the propensity matching: age, gender, diabetes history, LVEF, priority of surgery, pre-op haemoglobin \& SCr levels, cardiac surgery performed, CPB duration, Euroscore or LogEuroscore, RRT use, post-op D1\&/or D2 \&/or D3 SCr

What they're measuring

CSA-AKI

Timeframe: 6 months

CSA-AKI

Timeframe: 6 months

Trial details

NCT IDNCT07108634

SponsorThe Royal Wolverhampton Hospitals NHS Trust

Sponsor typeOTHER_GOV

Study typeOBSERVATIONAL

Primary completion2027-03

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