Glove Compression for Chemotherapy-Induced Neuropathy

Inclusion Criteria: * Female patients aged ≥18 years * Histologically confirmed gynecologic malignancy (e.g., ovarian, or endometrial cancer) * Scheduled to receive carboplatin-paclitaxel chemotherapy administered every 21 days * Planned for a total of six chemotherapy cycles * ECOG performance status 0-2 * Ability to provide written informed consent Exclusion Criteria: * Patients receiving neoadjuvant chemotherapy with planned surgery * Patients receiving weekly (dose-dense) paclitaxel regimens * Prior exposure to neurotoxic chemotherapy agents (e.g., taxanes, platinum compounds, proteasome inhibitors, anti-tubulin agents) * History of pre-existing peripheral neuropathy * Known allergy to latex or surgical gloves * Diagnosed peripheral vascular disease * Concurrent use of medications that may mask or modulate neuropathy symptoms (e.g., gabapentinoids, SNRIs, vitamin B complex, alpha-lipoic acid) * Clinical diagnosis of diabetic neuropathy or history of alcohol-related neuropathy * Raynaud's phenomenon or other cold-sensitive vascular conditions * Other neurological disorders that may interfere with neuropathy assessment * Refusal or inability to provide informed consent