Gastric Emptying With Metoclopramide in GLP-1 Agonist Patients Undergoing Elective Surgery (NCT07100691) | Clinical Trial Compass
Not Yet RecruitingPhase 4
Gastric Emptying With Metoclopramide in GLP-1 Agonist Patients Undergoing Elective Surgery
Ireland80 participantsStarted 2025-08
Plain-language summary
This is a multicentre, investigator-blinded, randomised controlled trial evaluating whether the use of oral metoclopramide before surgery can reduce the amount of residual gastric content in patients who are taking glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for weight loss. These medications are known to slow down gastric emptying, which may increase the risk of pulmonary aspiration during anaesthesia. Patients will be randomly assigned to either receive metoclopramide 24 hours before surgery or continue with standard care. The primary outcome will be the presence or absence of residual gastric content on ultrasound before surgery. Secondary outcomes include nausea, vomiting, constipation, and any adverse effects of the medication.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients taking GLP-1 receptor agonists (for weight loss only)
* Male and female patients aged 18 years or older
* Able to provide written informed consent
* ASA grade I-V
* Scheduled for elective surgery with an expected overnight hospital stay
Exclusion Criteria:
* Inability to provide informed consent
* Presence of hiatus hernia
* History of any gastric surgery
* Pregnancy
* Inability to lie in the right lateral decubitus position
* Patients taking chronic opioids
* Poorly controlled diabetes (HbA1c \>69 mmol/mol)
* Urgent or emergency surgery, including trauma
* Diagnosis of Parkinson's disease
* Allergy or intolerance to metoclopramide
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Presence of residual gastric content on preoperative gastric ultrasound
Timeframe: On the day of surgery prior to anaesthesia induction