An Exploratory Study on NK Cell-assisted Prevention of Bone Marrow Suppression During Chemotherap… (NCT07096583) | Clinical Trial Compass
Active — Not RecruitingPhase 1/2
An Exploratory Study on NK Cell-assisted Prevention of Bone Marrow Suppression During Chemotherapy for Ovarian Cancer
China20 participantsStarted 2025-07-07
Plain-language summary
To evaluate the remission effect and safety of intravenous injection of METR-NK cells as adjuvant therapy on bone marrow suppression in patients with ovarian cancer after chemotherapy
Who can participate
Age range18 Years – 70 Years
SexFEMALE
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18-70 years old (≥18, ≤70);
* Confirmed by pathology of high grade serous ovarian cancer, high level of endometrial carcinoma, and/or primary peritoneal carcinoma fallopian tube carcinoma epithelial ovarian cancer;
* ECOG score: 0-1;
* before, during, and after treatment of blood specimen can obtain, and the participants agreed to expand blood samples to central laboratory for the trial research purposes.;
* Expectations alive at least 3 months;
* Laboratory examination indexes meet the following requirements
* (1) renal function: Cr ULN or less (upper limit of normal) x 1.5, endogenous creatinine clearance rate (Ccr) or 60 ml/min;
* (2) the liver function: the total bilirubin ULN x 1.5 or less; ALT and AST≤ULN×2.5; (If there is intrahepatic cholangiocarcinoma or liver metastasis, the total bilirubin level should be less than 3 times the upper limit of normal, and the aminotransferase level should be less than 5 times the upper limit of normal); The neutrophilic granulocyte count
* Women of childbearing age agreed to during the study and research within 6 months after the end of contraception, And non-lactating patients;
* Participants can understand the research situation and voluntarily signed informed consent. No serious complications such as active digestive tract hemorrhage, perforation, jaundice, gastrointestinal obstruction, non cancerous fever \> 38 ℃;
* Expected, adherence to the good curative effect and adverse reaction will be effected ac…