The goal of this clinical trial is to evaluate the effectiveness of an advanced platelet-rich fibrin plus (A-PRF+) revascularization procedure to promote healing and root development in necrotic immature permanent single-rooted teeth in children and adolescents aged 8 to 18 years. The main questions it aims to answer are: * Does the A-PRF+ protocol improve root length, dentinal wall thickness, and apical closure compared to traditional calcium hydroxide apexification treatment? * Does A-PRF+ promote restoration of pulp vitality and reduce clinical symptoms such as pain, inflammation, or tooth discoloration? Results from the A-PRF+ treatment group will be compared with those from a historical control group receiving traditional calcium hydroxide apexification to evaluate relative effectiveness. Participants will: * Receive treatment following the A-PRF+ protocol, which includes disinfecting the tooth canal, applying an autologous platelet-rich fibrin scaffold, and sealing with glass ionomer cement; * Undergo clinical and radiographic follow-up visits at 1, 3, 6, 9, and 12 months; * Have pulp vitality tested with cold, electric, and laser Doppler flowmetry methods; * Be monitored for clinical symptoms, healing progress, and restoration performance. This study will help determine whether A-PRF+ is a safe and effective alternative to conventional apexification for regenerating necrotic immature teeth in young patients.
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Root Lengthening
Timeframe: From enrollment through 12 months post-treatment
Dentinal Wall Thickening
Timeframe: From enrollment through 12 months post-treatment
Apical Closure
Timeframe: From enrollment through 12 months post-treatment