A Study for Cerebral Open Flow Microperfusion

Inclusion Criteria * ECOG performance status (PS) 0, 1 or 2. * Clinical and radiographic evidence diagnosis of glioma, or a prior diagnosis of glioma (suspected WHO grade II-IV), OR clinical evidence of epileptic foci requiring a temporal lobectomy. * Clinical indication for resection as part of routine clinical care, with plan for this to be performed at Mayo Clinic (Rochester, MN). * Able and willing to provide informed consent either signed by themselves or a legally authorized representative. Exclusion Criteria * Vulnerable populations: pregnant women, prisoners or the mentally handicapped. * Patients who are not appropriate candidates for surgery due to current or past medical history or uncontrolled concurrent illness. * Patients whom the surgeon deems to be at increased risk of adverse effects from the study.