PRECISION-CPR: PRecision-Controlled Ventilation in CPR (NCT07088120) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
PRECISION-CPR: PRecision-Controlled Ventilation in CPR
United States, Mexico852 participantsStarted 2026-09-01
Plain-language summary
Cardiac arrest is a life-threatening emergency that requires immediate treatment with cardiopulmonary resuscitation (CPR). While chest compressions circulate blood, manual ventilation provides oxygen to the patient. Current CPR guidelines recommend specific ventilation rates and tidal volumes, but studies show that clinicians often deliver too much or too little ventilation due to a lack of monitoring tools, potentially reducing the effectiveness of CPR and impacting survival.
The PRECISION-CPR study is a multi-center, randomized controlled trial designed to evaluate whether using real-time feedback devices to precisely control ventilation during CPR can improve patient outcomes. Adult patients experiencing in-hospital cardiac arrest will be randomized to receive either standard manual ventilation guided by clinician experience or precision-controlled ventilation tailored to the patient's predicted body weight using real-time monitoring devices.
The primary outcome of the study will be return of spontaneous circulation (ROSC). Secondary outcomes will include survival to hospital discharge, neurological recovery, and other clinical measures. By addressing the limitations of current ventilation practices, this study aims to generate evidence to guide future resuscitation guidelines and improve survival rates after cardiac arrest.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult patients (18 years or older) with in-hospital cardiac arrest receiving manual ventilation via bag-mask or artificial airway
Exclusion Criteria:
* Inability to estimate predicted body weight (e.g., extreme body habitus or lack of height data).
* Patients receiving Extracorporeal Membrane Oxygenation (ECMO).
* Known pregnancy.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is testing a specific type of controlled ventilation during CPR for cardiac arrest — can you explain how 'precision-controlled ventilation' is different from standard CPR ventilation, and whether that difference might matter for someone in my situation?
2The trial isn't recruiting yet, so if we're interested in it, how long might it realistically be before enrollment opens, and is there any standard treatment or other option I should be pursuing in the meantime?
3The primary outcome being measured is Return of Spontaneous Circulation — can you help me understand what that means in practice, and what happens after ROSC in terms of recovery and longer-term outcomes?
4Since this trial is listed as Phase NA, what does that tell us about how much safety and effectiveness data already exists for this ventilation approach, and how should that affect our thinking about whether this could be worth exploring?
5Are there other clinical trials or established treatments for cardiac arrest that are already enrolling or proven, that you'd want me to consider alongside or before this one?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Return of Spontaneous Circulation (ROSC)
Timeframe: During resuscitation (up to 60 minutes after cardiac arrest onset)