The purpose of this study is to assess the safety of 3 doses of 2 new Strep A vaccine formulations, one with an Alum adjuvant, and the other with AS37 adjuvant. The Strep A vaccine will be tested for the first time in humans, in healthy young adults 18 to 25 years of age. The study will also assess if the vaccines have any immediate reactions and if they induce an immune response. A low, medium, and high dose of each formulation of the vaccine will be assessed in sequence.
Age range
18 Years – 25 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Number of participants with solicited administration site events
Timeframe: Up to 7 days after each study intervention administration occurring at Day 1, Day 31, and Day 121
Number of participants with solicited systemic events
Timeframe: Up to 7 days after each study intervention administration occurring at Day 1, Day 31, and Day 121
Number of participants with unsolicited adverse events (AEs)
Timeframe: Up to 30 days after each study intervention administration occurring at Day 1, Day 31, and Day 121
Number of participants with laboratory abnormalities
Timeframe: 7 days after each study intervention administration at Day 8, Day 38, and Day 128
Number of participants with adverse events of special interest (AESIs)
Timeframe: From Day 1 to Day 301
Number of participants with serious adverse events (SAEs)
Timeframe: From Day 1 to Day 301
Number of participants with AEs leading to withdrawal from the study or to discontinuation of study vaccine
Timeframe: From Day 1 to Day 301