CompletedNot Applicable

Remote Mindfulness Training Following Early Life Adversity 2

United States15 participantsStarted 2025-07-15

Plain-language summary

This pilot study aims to evaluate the effects of a 10-week online Mindfulness-Based Stress Reduction (MBSR) intervention on stress and inflammatory outcomes in a sample of emerging adults with a history of early life adversity. 15 participants (ages 18-29) with a history of childhood trauma will receive online, group-based MBSR sessions over 10 weeks. At pre- and post-intervention, participants will complete laboratory assessments, including self-report questionnaires and blood sample collection to assess markers of inflammation. Data assessing subjective and physiological stress in daily life will be collected for one week at pre- and post-intervention. This preliminary data will be used to test effects of online MBSR on health-relevant outcomes among young adults with a history of childhood trauma.

Who can participate

Age range18 Years – 29 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Ages 18-29 years * English speaking * History of adverse childhood experiences (specifically, moderate-to-severe physical, emotional, or sexual abuse in childhood: scoring \>9, \>12, or \>7 on respective Childhood Trauma Questionnaire subscales) * Data-enabled Android or iOS smartphone * Able to meet study requirements Exclusion Criteria: * Self-reported diagnosis of chronic physical disease (e.g., cancer, HIV, heart disease, diabetes, bleeding disorder) * Self-reported diagnosis of chronic mental disorder (e.g., schizophrenia, personality disorder, or psychotic illness), major neurological disorder, or suicidal thoughts or wishes at baseline * Medication use that interferes with HPA-axis activity (e.g., corticosteroids), autonomic activity (e.g., antihypertensive medication), inflammatory activity (e.g., cholesterol medications), or blood clotting * Current antibiotic, antiviral, or antimicrobial treatment * Shift workers * Pregnancy * Substance use disorder * Regular systematic mind-body practice (\>2 times per week)

What they're measuring

Change in Daily Life Subjective Stress: State Perceived Stress

Timeframe: change in stress assessed in daily life for 1 week at two timepoints: pre-intervention ambulatory assessment and post-intervention ambulatory assessment (an average of 11 weeks)

Change in Daily Life Subjective Stress: Daily Perceived Stress

Timeframe: change in stress assessed in daily life for 1 week at two timepoints: pre-intervention ambulatory assessment and post-intervention ambulatory assessment (an average of 11 weeks)

Change in Daily Life Objective Stress: Stress Events in the Past 2.5 Hours

Timeframe: change in stress assessed in daily life for 1 week at two timepoints: pre-intervention ambulatory assessment and post-intervention ambulatory assessment (an average of 11 weeks)

Change in Daily Life Objective Stress: Daily Stress Events

Timeframe: change in stress assessed in daily life for 1 week at two timepoints: pre-intervention ambulatory assessment and post-intervention ambulatory assessment (an average of 11 weeks)

Change in Daily Life Physiological Stress Reactivity

Timeframe: change in HR reactivity assessed in daily life for 1 week at two timepoints: pre-intervention ambulatory assessment and post-intervention ambulatory assessment (an average of 11 weeks)

Trial details

NCT IDNCT07085052

SponsorUniversity of Pittsburgh

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-12-16

View on ClinicalTrials.gov More Stress trials

Plain-language summary

Who can participate

Age range18 Years – 29 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in Daily Life Subjective Stress: State Perceived Stress

Timeframe: change in stress assessed in daily life for 1 week at two timepoints: pre-intervention ambulatory assessment and post-intervention ambulatory assessment (an average of 11 weeks)

Change in Daily Life Subjective Stress: Daily Perceived Stress

Timeframe: change in stress assessed in daily life for 1 week at two timepoints: pre-intervention ambulatory assessment and post-intervention ambulatory assessment (an average of 11 weeks)

Change in Daily Life Objective Stress: Stress Events in the Past 2.5 Hours

Timeframe: change in stress assessed in daily life for 1 week at two timepoints: pre-intervention ambulatory assessment and post-intervention ambulatory assessment (an average of 11 weeks)

Change in Daily Life Objective Stress: Daily Stress Events

Timeframe: change in stress assessed in daily life for 1 week at two timepoints: pre-intervention ambulatory assessment and post-intervention ambulatory assessment (an average of 11 weeks)

Change in Daily Life Physiological Stress Reactivity

Timeframe: change in HR reactivity assessed in daily life for 1 week at two timepoints: pre-intervention ambulatory assessment and post-intervention ambulatory assessment (an average of 11 weeks)