Magnetic Resonance Imaging-guided Online Adaptive Radiotherapy of Pelvic Lymph Node Metastases (NCT07083648) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Magnetic Resonance Imaging-guided Online Adaptive Radiotherapy of Pelvic Lymph Node Metastases
Switzerland20 participantsStarted 2025-07-16
Plain-language summary
In this study, the investigators want to investigate whether online-adapted radiotherapy using a special magnetic resonance imaging (MRI) simulator and computed tomography (CT)-guided radiation therapy, is feasible and offers advantages for the treatment of pelvic lymph node metastases.
Who can participate
Age range18 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Intra-pelvic and para-aortic lymph node metastases from a histologically confirmed malignancy;
* Indication for SBRT based on a multidisciplinary tumor board recommendation and / or clinical practice guideline;
* Intra-pelvic and para-aortic lymph node metastases confirmed by imaging and amenable for SBRT
Exclusion Criteria:
* Large body size that would not fit the MRI-simulator bore;
* Contraindications for MRI including but not limited to
* electronic devices such as pacemakers, defibrillators, deep brain stimulators, cochlear implants that are labeled as MR unsafe. Electronic devices labeled as MR safe or MR conditional are not a contraindication;
* metallic foreign body in the eye or aneurysm clips in the brain;
* severe claustrophobia;
* hip prosthesis that are labeled as MR unsafe;
* More than 5 pelvic lymph node metastasis
* Previous radiation therapy directly overlapping with SBRT in this study and leading to exceeding tolerance of OARs;
* History of Crohn's disease, ulcerative colitis