CompletedNot Applicable

Use of Injectable Extended Platelet-Rich Fibrin as a Local Drug Delivery in the Treatment of Stage II Periodontitis Patients

Egypt45 participantsStarted 2024-04-17

Plain-language summary

The objective of the present study is to assess the clinical effectiveness of local delivery of injectable extended platelet-rich fibrin in subgingival application when used in conjunction with scaling and root planing (SRP) in the treatment of stage II periodontitis. The primary outcome includes the clinical attachment gain after 6 months, whereas the secondary outcomes include the changes of probing pocket depth, bleeding on probing percentage, plaque and gingival indices and the concentration of matrix metalloproteinase-8 (MMP-8) in gingival crevicular fluid (GCF) after 3 and 6 months.

Who can participate

Age range30 Years – 50 Years

SexALL

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Inclusion criteria

✓. Patients with stage II Periodontitis (pocket depth ≤ 5mm and CAL = 3-4 mm).
✓. Age range (30-50) years.
✓. Good compliance with the plaque control instructions following initial therapy.
✓. Availability for follow- up and maintenance program.

Exclusion criteria

✕. Periodontitis patients with stage I, III and IV.
✕. Smoking.
✕. Systemic diseases which could influence the outcome of the therapy.
✕. Pregnant and lactating females.

What they're measuring

clinical attachment gain

Timeframe: 6 months

Trial details

NCT IDNCT07080294

SponsorMansoura University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-05-07

View on ClinicalTrials.gov More Periodontitis Stage II trials