Uptake and Excretion of a Single Dose of Oral 14C-labelled Polystyrene Microplastics in Healthy Volunteers

Inclusion Criteria: * Healthy males and females using contraception during and for 3 months after the study. * Aged from 18-65 years at the time of signing informed consent * 18.5 \< BMI \< 25 kg·m-2 * Must be willing and able to communicate and participate in the whole study * Must have regular bowel movements (i.e. average stool production of ≥1 and ≤3 stools per day) Exclusion Criteria: * Diabetes (Type 1, Type 2, or genetic form of diabetes) * Any diagnosed cardiovascular (heart) disease or high blood pressure (≥140 mmHg systolic and/or ≥90 mmHg diastolic) * History of clinically significant cardiovascular, renal, hepatic, chronic respiratory or gastro-intestinal disease, immunodeficiency, endocrine, neurological or psychiatric disorders * Known severe kidney problems * Subjects who have regular gastrointestinal complaints including abdominal pain, stomach upsets and borborygmi, known or suspected irritable bowel syndrome, or functional constipation * Recent or chronic history of diarrhoea * Known anaemia * Known impaired liver function * A personal or family history of thrombosis (clots), epilepsy, seizures, or schizophrenia. * Chronic use of any prescribed or over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices) * History of any drug or alcohol abuse in the past two years * A confirmed positive alcohol breath test at screening or admission * Any known food allergies or intolerances to the 14 major food allergens (celery, cereals c…