Chrono-restricted Diet and Physical Activity as a New Preventive Strategy for Sarcopenia in Postmenopausal Women With Obesity and Type 2 Diabetes

Inclusion Criteria: * Post-menopausal women (amenorrhea for at least 12 months, confirmed by gonadotrophins measures) * Age range 45-70 years * T2DM diagnosed for more than 1 year * Subjects with T2DM treated with lifestyle control alone or associated with metformine ± DPP4 inhibitors * Ability to sign written informed consent before any study-specific procedure * Subject considered as reliable and capable of adhering to protocol * Subjects with Body Mass Index (BMI)≥ 30 kg/m² * Baseline eating period ≥ 14 h per day (as estimated by 95% eating interval) Exclusion Criteria: * Subjects on T2DM injectable medication or drugs able to induce hypoglycemia (glinides, sulfonylurea) * Subjects with HbA1c \> 8% * Subjects with any of the following medical conditions: * Congestive cardiac failure * Stage 4 chronic kidney disease (i.e. eGFR \< 30 ml/min/1.73 m2) * Liver cirrhosis or chronic liver disease * Any medical condition that in the opinion of the investigator could jeopardize or compromise the subject's ability to participate in the study * Subjects with previous or present history of serious eating disorder * Subjects not able to understand the informed consent form or fasting diary instructions * Subjects currently participating or has participated in another study of an investigational medication or an investigational medical device within the last 30 days * Women with menopause hormone replacement therapy