The purpose of this study is to evaluate the safety and immunogenicity of different liponanaoparticle (LNP) formulations of modified ribonucleic acid (mRNA) vaccines using the RSV pre-F antigen in healthy participants 18 to 49 years of age. -Each participant will remain in the study for approximately 6 months. * The study intervention will be administered as a single intramuscular (IM) dose in the upper arm on Day 1 (D01). * The visit frequency will include 1 Screening Visit, 4 planned site visits to occur on D01, D03, D08, and D29, and 2 telephone calls to occur at Month (M)3 and M6.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Presence of any unsolicited systemic adverse events (aes)
Timeframe: Within 30 minutes after each vaccine injection
Presence of solicited injection site reactions (ie, pre-listed in the participant's diary and in the eCRF (electronic case report form)
Timeframe: Through 7 days after each vaccine injection
Presence of solicited systemic reactions (ie, pre-listed in the participant diary and in the CRF)
Timeframe: Through 7 days after each vaccine injection
Presence of unsolicited AEs
Timeframe: Day 1 through day 29
Presence of SAEs (Serious Adverse Events) and AESIs (Adverse Events of Special Interest)
Timeframe: Throughout study, approximately 6 months
Presence of out-of-range biological test results (including shift from baseline values)
Timeframe: Through 7 days after each vaccine injection
RSV A nAb (Neutralizing Antibodies) titers
Timeframe: At day 1 and day 29