A Randomized Controlled Study of the Efficacy and Safety of Lenalidomide in the Treatment of Acti… (NCT07068165) | Clinical Trial Compass
RecruitingPhase 2/3
A Randomized Controlled Study of the Efficacy and Safety of Lenalidomide in the Treatment of Active IgG4-related Disease
China198 participantsStarted 2025-07-07
Plain-language summary
For patients with active proliferative IgG4-RD, we plan to conduct a 52-week prospective randomized controlled trial to compare the efficacy and safety of 5mg lenalidomide plus prednisone, 10mg lenalidomide plus prednisone, and prednisone alone, so as to find new treatment measures for patients with proliferative IgG4-RD.
Who can participate
Age range18 Years – 75 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Patients aged between 18 and 75 years who meet the 2019 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for IgG4-RD；
✓. Patients with active disease: For patients with initial treatment or relapse after drug withdrawal, active disease is defined as having an IgG4-RD Response Index (RI) of at least 2 points in at least one organ at the time of screening; for those experiencing relapse while on treatment, active disease is defined as having an IgG4-RD RI of at least 3 points in at least one organ at the time of screening；
✓. Patients with the clinical subtype of proliferative IgG4-RD；
✓. Patients who have no plans for pregnancy within the next 18 months and who agree to use reliable contraceptive measures during the study period；
Exclusion criteria
✕. IgG4-RD patients with only fibrotic features;
✕. Absolute neutrophil count \<1.5×10\^9 /L or platelet count \<100×10\^9/L;
✕. Creatinine clearance less than 60 ml/ min;
✕. Liver function Child-Pugh grade B or above;
✕. Chronic active infection requiring systemic treatment;
✕. Diagnosed with malignant tumor in the past five years;
✕. Patients with a history of thrombosis;
✕
What they're measuring
1
Recurrence rate at 52 weeks
Timeframe: "From enrollment to the end of treatment at 52 weeks