A Randomized Clinical Trial Comparing Embryo Euploidy Rates Following Ultrashort Versus Standard … (NCT07062237) | Clinical Trial Compass
RecruitingNot Applicable
A Randomized Clinical Trial Comparing Embryo Euploidy Rates Following Ultrashort Versus Standard Abstinence
United States187 participantsStarted 2025-07-27
Plain-language summary
This research is being done to determine if producing sperm after an ultrashort period of abstinence (1 hour of abstinence) will be effective in improving the rates of embryos with normal chromosomes (structures that carry genetic information) during in vitro fertilization (IVF) treatment. The investigators hypothesize that a shorter period of abstinence is effective at improving rates of normal chromosomes among embryos.
Who can participate
Age range18 Years – 42 Years
SexALL
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Inclusion Criteria:
* Subjects are nonpregnant females ≥ 18 years and ≤ 42 years of age.
* Subjects obtain greater than or equal to 6 mature oocytes at the time of oocyte retrieval for ICSI or greater than or equal to 8 oocytes at the time of oocyte retrieval for standard insemination.
* Subjects are utilizing standard insemination or ICSI for fertilization.
* Subjects are undergoing PGT-A (PGT for aneuploidy) or PGT-M (PGT for monogenic disorders).
* Subjects are willing to comply with study protocol and procedures and provide written informed consent.
Exclusion Criteria:
* Subjects are utilizing donor oocytes, donor sperm, or gestational carrier.
* Subjects have a diagnosis of cryptozoospermia (no spermatozoa identified in fresh semen sample).
* Subjects are utilizing surgically removed sperm (e.g. via testicular sperm aspiration \[TESA\] or microsurgical epididymal sperm aspiration \[MESA\]).
* Subjects are utilizing frozen/thawed sperm, including in cases in which a fresh sample was planned and the sample is insufficient for use.
* Subjects are utilizing frozen/thawed oocytes.
* Subjects undergoing PGT-SR (PGT for structural rearrangements).
* Subjects are undergoing a day 3 (cleavage stage) embryo transfer.
* Subjects obtain less than 6 mature oocytes at the time of oocyte retrieval for ICSI or less than 8 oocytes at the time of oocyte retrieval for standard insemination.
* Subjects obtain greater than or equal to 6 mature oocytes at the time of oocyte retrieval for I…