The Effects of Chicory Root-derived Prebiotic on Mood and Stress Responsiveness in Healthy Adults… (NCT07058324) | Clinical Trial Compass
RecruitingNot Applicable
The Effects of Chicory Root-derived Prebiotic on Mood and Stress Responsiveness in Healthy Adults With Mild to Moderate Levels of Stress and Anxiety
Germany204 participantsStarted 2025-06-02
Plain-language summary
Emerging evidence from preclinical research suggests that prebiotic fibres may play a beneficial role in supporting mental health through modulation of the gut-brain axis-a complex communication network linking the gastrointestinal tract and the central nervous system. Chicory root-derived prebiotic fibre, already well-established for its positive effects on glycaemic control and bowel regularity, has recently shown promise in this context. The present study aims to investigate the mental health benefits of chicory root fibre in a larger and more diverse population, thereby contributing to the growing body of evidence supporting nutritional strategies for mental well-being.
Who can participate
Age range18 Years – 70 Years
SexALL
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Inclusion criteria
✓. Volunteer is healthy at the time of screening.
. Previous history of renal, hepatic, cardiovascular disease or clinically significant diabetes.
✕. Gastrointestinal disorders including irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) or other conditions that might affect the gut environment.
✕. Contraindication or allergy to any substance in the verum or placebo product incl. lactose or fructose intolerance.
✕. Use of drugs (e.g., antibiotics, aspirin, proton pump inhibitors) influencing gastrointestinal function in the previous 8 weeks before the beginning of intervention.
✕. Use of laxatives and labelled pre-and probiotics in the previous 4 weeks before the beginning of intervention.
✕. Participation in another study with any investigational product within 30 days of screening or during the study.