Allergic Bronchopulmonary Aspergillosis is a rare pulmonary disease involving allergic mechanisms, which historically affects patients with asthma or cystic fibrosis only. It is a source of respiratory decompensation. Its diagnosis requires the detection of total IgE, Aspergillus fumigatus-specific IgE, a chest X-ray or CT scan, Aspergillus fumigatus IgG and blood eosinophil measurement. These diagnostic criteria have several limitations in clinical practice. Indeed, radiographic abnormalities can be labile, and normal chest imaging therefore does not exclude the diagnosis but must be repeated. Similarly, blood eosinophils vary over time and are lowered by corticosteroid therapy. Finally, Aspergillus fumigatus specific IgE, when positive, does not allow us to distinguish simple sensitization from a true allergy to Aspergillus fumigatus.
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Dosage of IgE (rAsp f1) directed against recombinant antigens of Aspergillus fumigatus
Timeframe: day 1
Dosage of IgE ( rAsp f2) directed against recombinant antigens of Aspergillus fumigatus
Timeframe: day 1
Dosage of IgE (rAsp f3) directed against recombinant antigens of Aspergillus fumigatus
Timeframe: day 1
Dosage of IgE (rAsp f4) directed against recombinant antigens of Aspergillus fumigatus
Timeframe: day 1
Dosage of IgE (rAsp f6) directed against recombinant antigens of Aspergillus fumigatus
Timeframe: day 1