Repetitive Transcranial Magnetic Stimulation Combined With Bimanual Therapy for Upper Limb Stroke… (NCT07054424) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Repetitive Transcranial Magnetic Stimulation Combined With Bimanual Therapy for Upper Limb Stroke Rehabilitation
Taiwan54 participantsStarted 2025-07-15
Plain-language summary
The goal of this clinical trial is to evaluate whether combining repetitive transcranial magnetic stimulation (rTMS) with machine-assisted bimanual therapy (BT) can improve upper limb function in stroke patients. The participants will be individuals aged 40-80 years who have experienced a first-time ischemic or hemorrhagic stroke. The main questions it aims to answer are:
* Does the combined therapy enhance motor recovery compared to traditional rehabilitation methods?
* Are changes in brain activity associated with improvements in upper limb function?
Participants will be randomly assigned to different groups and will:
* Receive rTMS stimulation on specific areas of the brain to modulate neural activity,
* Perform machine-assisted bimanual exercises to promote motor skills, and
* Undergo assessments before, immediately after, and during follow-up periods to measure functional improvements.
Who can participate
Age range40 Years – 80 Years
SexALL
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Inclusion criteria
✓. Age 40-80 years;
✓. First-onset stroke patients;
✓. Patients diagnosed with cerebral infarction or hemorrhage through CT or MRI;
✓. Signed informed consent form by the patient and their family;
✓. Stable physiological parameters;
✓. Stroke occurred within the last 12 months;
✓. Patients with unilateral hand function impairment caused by the stroke;
✓. Upper limb muscle tone (Modified Ashworth Scale, MAS) less than 3 points;
Exclusion criteria
✕. A history of epilepsy or family history of epilepsy;
✕. Presence of suicidal tendencies;
✕. Currently using medications that lower the seizure threshold;
What they're measuring
1
Fugl-Meyer Assessment for Upper Extremity (FMA-UE)
Timeframe: Evaluated at before and after (immediately following the final sessions) the intervention. Additionally, follow-up assessments are conducted at 1 month and 3 months post-treatment to evaluate sustained effects.