This is a Phase 1, open-label, randomized, two-part study to evaluate the relative bioavailability (rBA) of two tablet formulations compared to the capsule formulation of ZN-A-1041 (Part 1). Part 2 of the study will evaluate the effect of food and rabeprazole on the ZN-A-1041 tablet formulation. No participants were enrolled in Part 2 of the study as it has been cancelled.
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Maximum Observed Concentration (Cmax)
Timeframe: Days 1-12 (Part 1)
Area Under the Concentration-Time curve from Hour 0 to the Last Measurable Concentration (AUC0-t)
Timeframe: Days 1-12 (Part 1)
AUC Extrapolated to Infinity (AUC0-inf)
Timeframe: Days 1-12 (Part 1)
Geometric Mean Ratio and Associated 90% Confidence Interval (CI) of Cmax
Timeframe: Days 1-12 (Part 1)
Geometric Mean Ratio and Associated 90% CI of AUC0-t
Timeframe: Days 1-12 (Part 1)
Geometric Mean Ratio and Associated 90% CI of AUC0-inf
Timeframe: Days 1-12 (Part 1)