CompletedPhase 1

Effect of Different Doses Of Intrathecal Dexmedetomidine In Combination With Bupivacaine On Spinal Anesthesia

Egypt90 participantsStarted 2023-07-01

Plain-language summary

This study is designed to assess the efficacy of different doses of dexmedetomidine in combination with intrathecal hyperbaric bupivacaine on spinal anesthesia and its postoperative analgesic characteristics on patients undergoing infra-umbilical procedures. Primary outcome: To ascertain a safe intrathecal dexmedetomidine dose for patients undergoing elective lower abdominal and lower limb surgeries Secondary outcomes: Assessment of level of sedation. Assessment of hemodynamic parameters (Blood Pressure -Heart Rate). Assessment of level of sensory \& motor block. Assessment of pain.

Who can participate

Age range18 Years – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18-60 years of either sex. * American Society of Anesthesiologists physical status I and II. * undergoing elective lower abdominal and lower limb surgeries under planned subarachnoid block. Exclusion Criteria: * patient refusal * contraindication to subarachnoid block (hypersensitivity to the drugs - infection at the site of injection) * significant comorbid conditions like congestive heart failure, coagulopathy, heart block * pregnancy.

What they're measuring

intrathecal dexmedetomidine dose

Timeframe: 2 hours

A safe intrathecal dexmedetomidine dose for patients

Timeframe: Intraoperative during 2 hours

Trial details

NCT IDNCT07051512

SponsorTanta University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-06-30

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