RecruitingNot Applicable

TO DETERMINE THE EFFECT OF ALLOGRAFT AND iPRF WITH OR WITHOUT COLLAGEN MEMBRANE ON HEALING OF APICOMARGINAL DEFECTS

India50 participantsStarted 2025-04-18

Plain-language summary

To determine the effect of allograft and iPRF with or without collagen membrane on healing of apicomarginal defects : A Randomized Controlled Trial

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Patients with no general medical contraindications for oral surgical procedures (ASA-I and ASA-II according to the classification of the American Society of Anesthesiologist's).
✓. Patients aged 18 years and above, presenting with chronic suppurative apical periodontitis in at least one tooth,
✓. Radiographic evidence of apical radiolucency with periodontal pocket depth exceeding 6 mm confined to buccal aspect of the root.
✓. Repeated abscess discharge despite satisfactory root canal treatment. 5.Patients with apicomarginal defects showing a denuded buccal bone plate
✓.Failed primary root canal treatment 7.Adequate final restoration with no clinical evidence of coronal leakage.

✕. Clinical or radiographic evidence of root fracture.
✕. Resorptive processes involving more than apical third of the root.
✕. Chronic generalized periodontitis.
✕. Failed previous endodontic surgery or failed root canal re-treatment.
✕. Any systemic disease contraindicating oral surgery including uncontrolled diabetes and pregnancy, any condition effecting rate of healing like smoking.

Periapical healing assessment

Timeframe: Base line to 12 months

NCT IDNCT07048171

SponsorPostgraduate Institute of Dental Sciences Rohtak

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-04-18

DR. Sanjay Tewari, MDS

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Patients with no general medical contraindications for oral surgical procedures (ASA-I and ASA-II according to the classification of the American Society of Anesthesiologist's).
✓. Patients aged 18 years and above, presenting with chronic suppurative apical periodontitis in at least one tooth,
✓. Radiographic evidence of apical radiolucency with periodontal pocket depth exceeding 6 mm confined to buccal aspect of the root.
✓. Repeated abscess discharge despite satisfactory root canal treatment. 5.Patients with apicomarginal defects showing a denuded buccal bone plate
✓.Failed primary root canal treatment 7.Adequate final restoration with no clinical evidence of coronal leakage.

✕. Clinical or radiographic evidence of root fracture.
✕. Resorptive processes involving more than apical third of the root.
✕. Chronic generalized periodontitis.
✕. Failed previous endodontic surgery or failed root canal re-treatment.
✕. Any systemic disease contraindicating oral surgery including uncontrolled diabetes and pregnancy, any condition effecting rate of healing like smoking.