Treatment of Bile Acid Diarrhoea With Atorvastatin

Inclusion Criteria: * age 18 years or above * Self-identification as White * Confirmed moderate-severe bile acid diarrhoea with a SeHCAT test result of ≤ 10 % * Reported number of average daily stools ≥ 3 stools per day * Reported number of average daily watery (6 or 7 on the Bristol Stool Chart) stools ≥ 1 stools per day(30) * Informed and written consent Exclusion Criteria: * Unwillingness to pause any of the following medications during the trial: bile acid sequestrants, morphine medication, liraglutide or anti-constipation medication (e.g., lactulose, laxoberal, magnesia) * Unwillingness to pause any anti-diarrhoea medication (e.g., imodium) from 3 days before initiation of each stool diary until after the respective visit * If regularly administering psyllium or metformin, unwillingness to agree to a stable dose of psyllium or metformin throughout the trial * Concomitant use of any drug in the GLP-1 receptor agonist drug class with the exception of paused liraglutide, see above * Concomitant use of any kind of insulin medication * Planned major changes in food consumption throughout the trial, including planned weight loss attempts * Prior use of any statin within the recent 6 months * Intake of larger quantities of grapefruit juice during trial participation, at the discretion of the investigator * History of/present hepatobiliary disorder (except for simple metabolic dysfunction-associated fatty liver disease) and/or alanine aminotransferase and/or serum aspartate a…