A Clinical Trial Comparing Low-Dose RT + Targeted Therapy+ Immunotherapy vs Targeted Therapy+ Imm… (NCT07040956) | Clinical Trial Compass
RecruitingPhase 2
A Clinical Trial Comparing Low-Dose RT + Targeted Therapy+ Immunotherapy vs Targeted Therapy+ Immunotherapy Alone as Neoadjuvant Therapy in Operable HNSCC Patients.
China98 participantsStarted 2025-06-28
Plain-language summary
This study aimed to compare the efficacy of neoadjuvant low-dose radiotherapy combined with targeted therapy and immunotherapy versus targeted therapy and immunotherapy alone in patients with resectable head and neck squamous cell carcinoma.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Age 18 years or above.
✓. Patients with pathologically confirmed HNSCC (except for nasopharyngeal carcinoma) and meet the following condition:
✓. Written informed consent.
Exclusion criteria
✕. History of other malignancies (except for the history of malignant tumors that have been cured and have not recurred within 5 years, such as skin basal cell carcinoma, skin squamous cell carcinoma, superficial bladder cancer, in situ cervical cancer, and gastrointestinal mucosal cancer, etc.）
✕. Have an active autoimmune disease requiring systemic treatment or a documented history of clinically severe autoimmune disease.
✕. Any history of allergic disease, or a severe hypersensitivity reaction to drugs, or allergy to the study drug components.
✕. Any of prior therapy with:
✕. With serious medical diseases, such as grade II and above cardiac dysfunction (NYHA criteria), ischemic heart disease, supraventricular or ventricular arrhythmia, poorly controlled diabetes mellitus, poorly controlled hypertension, echocardiographic ejection fraction \< 50%, etc.
✕. With interstitial pneumonitis, non-infectious pneumonitis, active pulmonary tuberculosis, or history of pulmonary tuberculosis infection that were not controlled by treatment.
✕. With hyperthyroidism, or organic thyroid disease.