Not Yet RecruitingNot Applicable

Comparison of Short Peptide and Whole Protein Formula in the Early Enteral Nutrition of Patients With Sepsis

80 participantsStarted 2025-06-25

Plain-language summary

To explore the effects of early enteral nutrition with short peptide formula on energy metabolism and clinical outcomes in patients with sepsis based on blood samples, clinical database, full-spectrum metabolomics test and imaging data, and to form a theoretical basis for optimizing the formula of early enteral nutrition in patients with sepsis.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion criteria

✓. Informed consent has been signed
✓. Aged from 18 to 80 years old
✓. Within 24 hours after admission to ICU
✓. Sepsis was diagnosed according to the 2016 International Sepsis 3.0 diagnostic criteria
✓. Without gastrointestinal perforation, bleeding, obstruction and other contraindications to enteral nutrition
✓. Expected ICU stay for more than 7 days

Exclusion criteria

✕. Receiving palliative care or expected to die within 72 hours
✕. Pregnant or breastfeeding
✕. Use of high dose vasopressor maintenance (norepinephrine dosage \> 0.5 μg/kg/min)
✕. Requiring restricted protein intake or additional protein supplementation (e.g., patients with hepatic encephalopathy, severe renal insufficiency, severe burns, severe malnutrition, etc..)

What they're measuring

Metabolomics changes form

Timeframe: On the 7th day after enrollment

Trial details

NCT IDNCT07038057

SponsorShanghai Zhongshan Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12-31

Contact for this trial

Yanni Zhang, MD, PhD

+86 13381819621 yanni99@126.com

View on ClinicalTrials.gov More Sepsis trials