This randomized controlled trial investigates the neurophysiological, physiological, and attentional effects of Cognitive-Behavioral Therapy (CBT) in individuals with restrictive-type anorexia nervosa (AN). The study compares two groups: one receiving a 12-week CBT intervention, and one placed on a waitlist (no active treatment during the study period). All participants undergo pre- and post-intervention assessments using electroencephalography (EEG), galvanic skin response (GSR), and eye-tracking while exposed to visual stimuli related to food, body image, and self-appearance. The primary outcomes include neural changes in attention and emotional processing (P300, LPP, frontal alpha asymmetry), physiological arousal (skin conductance), and visual attention biases (fixation duration and gaze distribution). The aim is to determine whether CBT leads to measurable improvements in neurobiological and attentional mechanisms related to body image disturbance and food-related anxiety in AN, contributing to biomarker-informed psychotherapy approaches.
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Change in EEG P300 amplitude in response to body image stimuli
Timeframe: aseline and Week 12
Change in Late Positive Potential (LPP) amplitude to body and food stimuli
Timeframe: Baseline and Week 12
Change in frontal alpha asymmetry during self-image viewing
Timeframe: Baseline and Week 12
Change in skin conductance response (SCR) to body and food stimuli
Timeframe: Baseline and Week 12
Change in fixation duration on weight-related body areas
Timeframe: Baseline and Week 12 Baseline and Week 12