Air Tamponade Versus Fluorinated Gas Tamponade for Rhegmatogenous Retinal Detachment (NCT07034469) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Air Tamponade Versus Fluorinated Gas Tamponade for Rhegmatogenous Retinal Detachment
150 participantsStarted 2026-03-20
Plain-language summary
TITLE: RCT of air tamponade versus fluorinated gas tamponade for rhegmatogenous retinal detachment DESIGN: Non-inferiority RCT of 150 patients from 10 UK centres AIMS: To assess whether air tamponade is non inferior to gas tamponade for the repair of RRD treated with vitrectomy.
PRIMARY OUTCOME MEASURE: Primary anatomical success with single operation at 24 weeks.
Who can participate
Age range40 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Primary uncomplicated RRD undergoing vitrectomy.
* Phakic and pseudophakic eyes
* Retinal breaks superiorly between 3 and 9 o'clock, and that are separated by less than 4 clock hours.
Exclusion Criteria:
* Absence of PVD
* Age 40 years or younger
* PVR grade C or above
* Aphakia or anterior chamber lens
* Retinal breaks greater than 1 clock hour in size
* Retinal breaks that exist below 3 and 9 o'clock on both the nasal and temporal sides.
* Retinal breaks at or posterior to the vessel arcades
* Current or previous -6D myopia or greater (or axial length \>26millimetres (mm))
* Chronic RRD judged by the presence of subretinal bands and other signs of -chronicity or by history of visual loss for \>28 days.
* Significant inflammation, choroidal detachments, hypotony (\<6 millimetres of mercury (mmHg) preop)
* Previous open-globe injury, or endophthalmitis
* Current or previous posterior uveitis or choroiditis
* Any intraocular surgical procedure within 4 weeks other than laser/cryotherapy
* Any other condition that, in the opinion of the investigator, would prevent the participant from granting informed consent or complying with the protocol.
What they're measuring
1
Primary anatomical success
Timeframe: 6 months
Trial details
NCT IDNCT07034469
SponsorLiverpool University Hospitals NHS Foundation Trust