Air Tamponade Versus Fluorinated Gas Tamponade for Rhegmatogenous Retinal Detachment (NCT07034469) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Air Tamponade Versus Fluorinated Gas Tamponade for Rhegmatogenous Retinal Detachment
150 participantsStarted 2026-03-20
Plain-language summary
TITLE: RCT of air tamponade versus fluorinated gas tamponade for rhegmatogenous retinal detachment DESIGN: Non-inferiority RCT of 150 patients from 10 UK centres AIMS: To assess whether air tamponade is non inferior to gas tamponade for the repair of RRD treated with vitrectomy.
PRIMARY OUTCOME MEASURE: Primary anatomical success with single operation at 24 weeks.
Who can participate
Age range
40 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Primary uncomplicated RRD undergoing vitrectomy.
* Phakic and pseudophakic eyes
* Retinal breaks superiorly between 3 and 9 o'clock, and that are separated by less than 4 clock hours.
Exclusion Criteria:
* Absence of PVD
* Age 40 years or younger
* PVR grade C or above
* Aphakia or anterior chamber lens
* Retinal breaks greater than 1 clock hour in size
* Retinal breaks that exist below 3 and 9 o'clock on both the nasal and temporal sides.
* Retinal breaks at or posterior to the vessel arcades
* Current or previous -6D myopia or greater (or axial length \>26millimetres (mm))
* Chronic RRD judged by the presence of subretinal bands and other signs of -chronicity or by history of visual loss for \>28 days.
* Significant inflammation, choroidal detachments, hypotony (\<6 millimetres of mercury (mmHg) preop)
* Previous open-globe injury, or endophthalmitis
* Current or previous posterior uveitis or choroiditis
* Any intraocular surgical procedure within 4 weeks other than laser/cryotherapy
* Any other condition that, in the opinion of the investigator, would prevent the participant from granting informed consent or complying with the protocol.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Primary anatomical success
Timeframe: 6 months
Trial details
NCT IDNCT07034469
SponsorLiverpool University Hospitals NHS Foundation Trust