Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and … (NCT07029438) | Clinical Trial Compass
CompletedPhase 4
Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and Gingivitis
United States228 participantsStarted 2025-07-07
Plain-language summary
The objective of this clinical research study is to evaluate the efficacy of floss to an essential oil alcohol-containing mouthwash, an essential oil alcohol-free mouthwash, and a CPC+Zn alcohol-free mouthwash in reducing dental plaque and gingivitis.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
* Male or female volunteers at least 18 years of age and in general good health.
* Willing and able to understand and sign the informed consent form.
* Whole mouth mean MGI ≥1.95, whole mouth mean TPI≥1.95, and ≥10% bleeding sites
* Be willing to conform to the study protocol and procedures.
* No sites with probing depth \>4 mm.
* Minimum of 20 natural teeth with scorable facial and lingual surfaces
Exclusion Criteria:
* Medical condition which requires premedication prior to dental visits/procedure.
* Known history of allergy to personal care/consumer products or their ingredients, relevant to any ingredients in the test products as determined by the study examiner.
* Active disease of the hard oral tissues.
* Significant oral soft tissue pathology, excluding plaque-induced gingivitis.
* Moderate to severe periodontitis (stages II-IV) per the EFP S3 guidelines.
* Subjects with fixed or removable orthodontic appliances or removable partial dentures.
* Dental prophylaxis within 30 days prior to study start.
* Use of antibiotics, antimicrobial drugs, anti-inflammatory drugs, or anticoagulant therapies within 30 days prior to study start.
* Use of chemotherapeutic oral care products within two weeks prior to study start.
* Participation in any other clinical study within 30 days prior to enrollment into this study.
* Subjects who must receive dental treatment during the study dates.
* Immunocompromised individuals (HIV, AIDS, immunosuppressive drug therapy…